Effects of bilateral stimulation of the subthalamic nucleus in patients with severe Parkinson's disease and motor fluctuations
Identifieur interne : 001899 ( Main/Exploration ); précédent : 001898; suivant : 001900Effects of bilateral stimulation of the subthalamic nucleus in patients with severe Parkinson's disease and motor fluctuations
Auteurs : Karen Stergaard [Danemark] ; Niels Sunde [Danemark] ; Erik Dupont [Danemark]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-07.
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Abstract
We present the efficacy and side effects of bilateral deep brain stimulation (DBS) of the subthalamic nuclei (STN) performed with a more simplified surgical procedure than described by the Grenoble group. A consecutive series of 26 patients with advanced and levodopa‐responsive Parkinson's disease and motor complications was evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS) part I–VI, timed tests, and a patient diary for 2 days concerning on–off phenomenon and dyskinesias. At 3 months, evaluation of stimulation by the UPDRS motor score was performed in a double‐blind manner and a significant improvement of 57% was found. The results 12 months after surgery off medication showed significant improvement in both UPDRS motor score and activities of daily living of 64% and, on medication, a significant reduction of 86% in duration of dyskinesias and 83% in duration of off‐periods. Reduction in medication was less than for other groups, probably because we used smaller doses of levodopa before the operation. No serious side effects were encountered. When the patients are carefully selected and followed up, bilateral DBS of STN is a significant progress in treatment of advanced idiopathic Parkinson's disease with levodopa‐induced motor complications. © 2002 Movement Disorder Society
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DOI: 10.1002/mds.10188
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-07">2002-07</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="693">693</biblScope><biblScope unit="page" to="700">700</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A4D5BCD874D884861ADBC402F5E70113F8B7533F</idno><idno type="DOI">10.1002/mds.10188</idno><idno type="ArticleID">MDS10188</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>activities of daily living (ADL)</term><term>deep brain stimulation</term><term>dyskinesias</term><term>motor score</term><term>nucleus subthalamicus</term><term>on–off phenomenon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We present the efficacy and side effects of bilateral deep brain stimulation (DBS) of the subthalamic nuclei (STN) performed with a more simplified surgical procedure than described by the Grenoble group. A consecutive series of 26 patients with advanced and levodopa‐responsive Parkinson's disease and motor complications was evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS) part I–VI, timed tests, and a patient diary for 2 days concerning on–off phenomenon and dyskinesias. At 3 months, evaluation of stimulation by the UPDRS motor score was performed in a double‐blind manner and a significant improvement of 57% was found. The results 12 months after surgery off medication showed significant improvement in both UPDRS motor score and activities of daily living of 64% and, on medication, a significant reduction of 86% in duration of dyskinesias and 83% in duration of off‐periods. Reduction in medication was less than for other groups, probably because we used smaller doses of levodopa before the operation. No serious side effects were encountered. When the patients are carefully selected and followed up, bilateral DBS of STN is a significant progress in treatment of advanced idiopathic Parkinson's disease with levodopa‐induced motor complications. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><country name="Danemark"><noRegion><name sortKey=" Stergaard, Karen" sort=" Stergaard, Karen" uniqKey=" Stergaard K" first="Karen" last=" Stergaard">Karen Stergaard</name></noRegion><name sortKey="Dupont, Erik" sort="Dupont, Erik" uniqKey="Dupont E" first="Erik" last="Dupont">Erik Dupont</name><name sortKey="Sunde, Niels" sort="Sunde, Niels" uniqKey="Sunde N" first="Niels" last="Sunde">Niels Sunde</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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